Key result
Cyclophosphamide treatment in mice chronically infected with T. cruzi increased delayed type hypersensitivity skin thickness and significantly increased the number of heart interstitial dendritic cells.
Population
BALB/c mice chronically infected with Trypanosoma cruzi
Comparison
Cyclophosphamide for one month vs No treatment
Design
Preclinical
Follow-up
1 month
Authors
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Hypothesis-generating for dendritic cell modulation in chronic Chagas; leaves open human translation and clinical relevance.
In a mouse model of chronic Trypanosoma cruzi infection, low-dose cyclophosphamide enhances delayed type hypersensitivity and increases heart interstitial dendritic cells, suggesting their role in regulating the immune response.
The et al. (2013) studied Trypanosoma cruzi infection. Cyclophosphamide vs. No treatment was evaluated on Delayed type hypersensitivity (DTH) skin test thickness and heart interstitial dendritic cells (IDCs) participation. Cyclophosphamide treatment in mice chronically infected with T. cruzi increased delayed type hypersensitivity skin thickness and significantly increased the number of heart interstitial dendritic cells.
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