Key result
Complete genome sequencing of two Coxsackievirus A1 strains isolated from healthy children revealed natural intertypic recombination events between CVA1 and CVA22 and demonstrated cytotoxicity to human rhabdomyosarcoma cells.
The study provides the complete genome sequences of two CVA1 strains capable of infecting RD cells, revealing natural recombination between CVA1 and CVA22.
Natural recombination in asymptomatic CVA1 strains supports expanded enteroviral surveillance; leaves open clinical relevance and pathogenicity in humans.
Coxsackievirus A1 (CVA1) belongs to human enterovirus species C within the family Picornaviridae, order Picornavirales. Two Chinese CVA1 isolates, HT-THLH02F/XJ/CHN/2011 and KS-ZPH01F/XJ/CHN/2011, were isolated from stool specimens of two healthy children in the Xinjiang Uygur autonomous region of China. They were found to elicit cytopathic effects in a human rhabdomyosarcoma cell line, and complete genome sequences of these two CVA1 isolates revealed that natural intertypic recombination events occurred between CVA1 and CVA22.
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Sun et al. (2012) studied Healthy (n=2). Coxsackievirus A1 strains (HT-THLH02F and KS-ZPH01F) was evaluated on Complete genome sequence and cytopathic effect in human rhabdomyosarcoma cells. Complete genome sequencing of two Coxsackievirus A1 strains isolated from healthy children revealed natural intertypic recombination events between CVA1 and CVA22 and demonstrated cytotoxicity to human rhabdomyosarcoma cells.
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