Key result
Angiopeptin treatment in rabbits with vascular injury enhanced acetylcholine-induced relaxation and reduced intimal hyperplasia by 36%.
Why the study?
Does angiopeptin improve neoendothelial function and inhibit intimal hyperplasia in rabbits with balloon catheter vascular injury?
Population
New Zealand White rabbits with balloon catheter injury of the thoracic and abdominal aorta
Comparison
Angiopeptin (BIM-23014) for 2 or 4 weeks vs Untreated rabbits at 2 or 4 weeks after injury…
Design
Preclinical
Follow-up
2 or 4 weeks
Authors
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Supports angiopeptin investigation for endothelial recovery after vascular injury; hypothesis-generating with no human translation yet.
Does angiopeptin improve neoendothelial function and inhibit intimal hyperplasia in rabbits with balloon catheter vascular injury?
Angiopeptin may inhibit intimal hyperplasia following vascular injury partly through beneficial effects on neoendothelial function.
Light et al. (1993) studied Vascular injury. Angiopeptin (BIM-23014) vs. Untreated rabbits and sham-operated controls was evaluated on Acetylcholine-induced relaxation, PGI2 formation, and intimal hyperplasia. Angiopeptin treatment in rabbits with vascular injury enhanced acetylcholine-induced relaxation and reduced intimal hyperplasia by 36%.
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