April 1, 1995Journal of Cardiovascular Pharmacology

Angiopeptin (BIM23014C) Inhibits Vascular Smooth Muscle Cell Migration In Vitro Through a G-Protein-Mediated Pathway and Is Associated with Inhibition of Adenylyl Cyclase and Cyclic AMP Accumulation

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Population

Rat aortic smooth muscle cells (RA-SMC) in vitro

Comparison

Angiopeptin (BIM23014C) at doses up to 100 nM vs Control or Angiopeptin with pertussis toxin

Design

Preclinical

Authors

DMDaniel L. MooradianUniversity of Minnesota CDClement A. DiglioWayne State University BLBruce R. LesterUniversity of Minnesota

Discussion

Member takes

Implication

Elucidates Gi-dependent mechanism for Angiopeptin in SMC migration; leaves open in vivo efficacy against intimal hyperplasia.

Structured PICO

Population

Rat aortic smooth muscle cells (RA-SMC) in vitro

Intervention

Angiopeptin (BIM23014C) at doses up to 100 nM

Comparator

Control (no Angiopeptin) or Angiopeptin with pertussis toxin

Outcome

RA-SMC migration in response to type I collagensurrogate

Angiopeptin inhibits vascular smooth muscle cell migration in vitro via a Gi-dependent pathway involving inhibition of adenylyl cyclase and cAMP accumulation, providing a mechanism for its prevention of intimal hyperplasia after balloon angioplasty.

Cite This Study

Mooradian et al. (1995) studied this question.

synapsesocial.com/papers/6a8175a89fceb4fbd5e3f46e https://doi.org/10.1097/00005344-199504000-00015

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Angiopeptin (BIM23014C) Inhibits Vascular Smooth Muscle Cell Migration In Vitro Through a G-Protein-Mediated Pathway and Is Associated with Inhibition of Adenylyl Cyclase and Cyclic AMP Accumulation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Angiopeptin (BIM23014C) Inhibits Vascular Smooth Muscle Cell Migration In Vitro Through a G-Protein-Mediated Pathway and Is Associated with Inhibition of Adenylyl Cyclase and Cyclic AMP Accumulation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider