Key result
Vascular risk factors including age, hypertension, atrial fibrillation, depression, intima-media thickness, and periventricular white matter hyperintensities were significantly associated with aMCI.
Why the study?
Are vascular risk factors and subclinical markers of atherosclerosis associated with amnestic mild cognitive impairment?
Case-Control (n=181)
Are vascular risk factors and subclinical markers of atherosclerosis associated with amnestic mild cognitive impairment?
Vascular risk factors, including hypertension, atrial fibrillation, and increased intima-media thickness, are significantly associated with amnestic mild cognitive impairment.
Supports vascular screening in aMCI evaluation; leaves open whether modification alters progression.
BACKGROUND AND OBJECTIVE: Current evidence shows that numerous classic vascular risk factors (VRF) contribute to mild cognitive impairment (MCI), but the effects of emerging VRFs are less well-known. Using a comprehensive approach, we assessed the frequency and strength of association between MCI and classic VRFs, subclinical markers of atherosclerosis (cystatin C, lipoprotein(a), high-sensitivity C-reactive protein, and intima-media thickness) and white matter hyperintensities (WMH). METHODS: In this case-control study of consecutive MCI patients and cognitively normal controls, subjects underwent clinical and neuropsychological examinations, laboratory analyses, a carotid duplex scan, and a brain magnetic resonance imaging scan. RESULTS: The study included 105 patients with amnestic MCI (aMCI): 24 with single domain amnestic MCI, 81 with multiple domain amnestic MCI, and 76 controls. Compared to controls, patients with aMCI were significantly older and had higher rates of arterial hypertension, atrial fibrillation, and depression. They also had a larger intima-media thickness and higher load of WMHs, both periventricular (WMHpv) and subcortical (WMHsc). In the adjusted analysis, all variables except WMHsc displayed a significant association with aMCI. Body mass index exerted a protective effect. CONCLUSIONS: Our findings suggest a direct association between aMCI and age, hypertension, atrial fibrillation depression, intima-media thickness, and WMHpv. Body mass index has a protective effect on this MCI subtype.
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Naranjo et al. (2015) conducted a case-control in amnestic mild cognitive impairment (n=181). Vascular risk factors vs. Cognitively normal controls was evaluated on Association with amnestic mild cognitive impairment. Vascular risk factors including age, hypertension, atrial fibrillation, depression, intima-media thickness, and periventricular white matter hyperintensities were significantly associated with aMCI.
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