Key result
Higher vascular risk burden linked to greater nonamnestic cognitive impairment odds in Black vs. White adults.
Why the study?
Prevalence differences of mild cognitive impairment among Black and white older adults motivated examination of whether vascular risk factor associations with MCI vary by race.
Does the association between vascular risk factors and mild cognitive impairment subtypes vary by race in older adults?
Observational (n=2,755)
Does the association between vascular risk factors and mild cognitive impairment subtypes vary by race in older adults?
Vascular risk factors such as high cholesterol and obesity are more strongly associated with nonamnestic mild cognitive impairment in Black older adults compared to white older adults.
Objectives: Given prevalence differences of mild cognitive impairment (MCI) among Black and white older adults, this study aimed to examine whether overall vascular risk factor (VRF) burden and individual VRF associations with amnestic (aMCI) and nonamnestic (naMCI) MCI status varied by Black/white race. Methods: Participants included 2755 older adults without dementia from the ACTIVE study. Comprehensive neuropsychological criteria were used to classify cognitively normal, aMCI, and naMCI. VRFs were primarily defined using subjective report and medication data. Multinomial logistic regression was run predicting MCI subtype. Results: Greater overall VRF burden, high cholesterol, and obesity evinced greater odds of naMCI in Black participants than whites. Across participants, diabetes and hypertension were associated with increased odds of aMCI and naMCI, respectively. Discussion: Results may reflect known systemic inequities on dimensions of social determinants of health for Black older adults. Continued efforts toward examining underlying mechanisms contributing to these findings are critical.
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Rotblatt et al. (2021) conducted an observational in Mild cognitive impairment (n=2,755). Vascular risk factor burden was evaluated on Amnestic (aMCI) and nonamnestic (naMCI) MCI status. Greater overall vascular risk factor burden, high cholesterol, and obesity were associated with greater odds of nonamnestic mild cognitive impairment in Black participants compared to whites.
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