Key result
Transcutaneous balloon dilation angioplasty produced an immediate 65% increase in coarctation diameter and a 68% decrease in systolic gradient, which persisted for up to 1 year.
Why the study?
Does transcutaneous balloon dilation angioplasty reduce the systolic gradient in an experimental lamb model of aortic coarctation?
Population
17 long-term survivor lambs with surgically created juxtaductal aortic coarctation
Comparison
Transcutaneous balloon dilation angioplasty with… vs Undilated control lambs (n=4)
Design
Preclinical
Follow-up
up to 1 year
Authors
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Supports feasibility in lamb coarctation model; leaves open translation to human coarctation pending clinical trials.
Does transcutaneous balloon dilation angioplasty reduce the systolic gradient in an experimental lamb model of aortic coarctation?
Transcutaneous balloon angioplasty successfully and durably reduced the systolic gradient in an experimental lamb model of aortic coarctation, supporting its potential feasibility in humans.
Lock et al. (1982) studied Experimental aortic coarctation (n=17). Transcutaneous balloon dilation angioplasty vs. Undilated controls was evaluated on Systolic gradient across the coarctation site and diameter of the coarctation. Transcutaneous balloon dilation angioplasty produced an immediate 65% increase in coarctation diameter and a 68% decrease in systolic gradient, which persisted for up to 1 year.
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