Key result
Familial amyloid polyneuropathy was associated with a higher mean myocardial muscarinic receptor density compared to controls (35.5 vs 26.1 pmol/mL; P=0.003).
Why the study?
Does familial amyloid polyneuropathy alter myocardial muscarinic receptor density and beta-receptor responsiveness compared to healthy controls?
Population
21 patients with familial amyloid polyneuropathy and control subjects
Comparison
Positron emission tomography withC-MQNB and… vs Control subjects
Design
Cross-sectional
Authors
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Should not change clinical practice in FAP; leaves open whether muscarinic upregulation affects outcomes or therapy response.
Case-Control (n=21)
Does familial amyloid polyneuropathy alter myocardial muscarinic receptor density and beta-receptor responsiveness compared to healthy controls?
Absolute Event Rate: 35.5% vs 26.1%
p-value: p=0.003
Familial amyloid polyneuropathy causes parasympathetic denervation leading to upregulation of myocardial muscarinic receptors, while beta-receptor responsiveness to catecholamines remains preserved.
Delahaye et al. (2001) conducted a case-control in Familial amyloid polyneuropathy (n=21). Familial amyloid polyneuropathy vs. Control subjects was evaluated on Mean muscarinic receptor density (B'max) (p=0.003). Familial amyloid polyneuropathy was associated with a higher mean myocardial muscarinic receptor density compared to controls (35.5 vs 26.1 pmol/mL; P=0.003).
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