Key result
Pressure load of the right ventricle, induced by either pulmonary trunk banding or chronic hypoxia, resulted in similar alterations in the expression of 172 genes, indicating pressure load is the primary driver of gene expression changes in right ventricular hypertrophy.
Why the study?
Does pressure load or hypoxia primarily drive altered gene expression in right ventricular hypertrophy in rats?
Population
94 male Wistar rats; 48 in the hypoxia experiment and 46 in the pulmonary trunk banding experiment.
Comparison
Pulmonary trunk banding or chronic hypobaric… vs Sham operation or normobaric normoxia.
Design
Preclinical, Animals were randomly selected for gene chip analysis, but…
Follow-up
Up to 4 weeks for hypoxia experiment and up to 6 weeks for…
Authors
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Rat models implicate pressure load over hypoxia in RV gene expression; leaves open translation to human PH therapies.
Does pressure load or hypoxia primarily drive altered gene expression in right ventricular hypertrophy in rats?
Pressure load, rather than hypoxia per se, is the primary driver of altered gene expression in right ventricular hypertrophy, suggesting that treatments for pulmonary hypertension should focus on reducing right ventricular pressure.
Baandrup et al. (2011) studied Right ventricular hypertrophy (n=94). Pulmonary trunk banding or chronic hypoxia vs. Sham operation or normoxia was evaluated on Gene expression changes in the right ventricle. Pressure load of the right ventricle, induced by either pulmonary trunk banding or chronic hypoxia, resulted in similar alterations in the expression of 172 genes, indicating pressure load is the primary driver of gene expression changes in right ventricular hypertrophy.
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