Key result
A novel surface ECG-based method to quantify action potential duration restitution dispersion correlated with simulated tissue-level dispersion, with a mean relative error below 5%.
Population
Control subjects undergoing a tilt test trial and 2-D ventricular tissue simulation models
Comparison
Noninvasive quantification of action potential… vs In silico 2-D ventricular tissue simulations (∆α)
Design
Preclinical
Authors
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Animal validation supports ECG restitution metrics; leaves open human arrhythmic risk utility.
A novel surface ECG-based method using the T-wave peak to end interval can accurately estimate ventricular action potential duration restitution dispersion, a potential marker of arrhythmic risk.
Mincholé et al. (2011) studied this question. Surface ECG-based estimation of APDR dispersion vs. Computational modeling and simulation was evaluated on Mean relative error between ECG estimates and simulated APDR dispersion. A novel surface ECG-based method to quantify action potential duration restitution dispersion correlated with simulated tissue-level dispersion, with a mean relative error below 5%.
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