Key result
In patients with congestive heart failure, sleep apnoea severity was an independent predictor of nighttime predominant T-wave alternans (OR 1.08; 95% CI 1.01-1.16; P=0.03).
Why the study?
Does sleep apnoea severity correlate with nocturnal cardiac electrical instability (T-wave alternans) in patients with congestive heart failure?
Population
40 patients with congestive heart failure (CHF)
Design
Cross-sectional
Follow-up
24 hours
Authors
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Supports hypothesis linking sleep apnoea to nocturnal arrhythmic risk in HF; hypothesis-generating and requires prospective validation before any practice implications.
Cross-Sectional (n=40)
Does sleep apnoea severity correlate with nocturnal cardiac electrical instability (T-wave alternans) in patients with congestive heart failure?
Odds Ratio: 1.08 (95% CI 1.01–1.16)
Absolute Event Rate: 35.9% vs 23.9%
p-value: p=0.03
In patients with congestive heart failure, sleep apnoea severity is independently associated with nocturnal T-wave alternans, suggesting a mechanism for the increased risk of nocturnal sudden cardiac death.
Takasugi et al. (2009) conducted a cross-sectional in Congestive heart failure (n=40). Sleep apnoea vs. Lower severity of sleep apnoea was evaluated on Nighttime predominant T-wave alternans (OR 1.08, 95% CI 1.01-1.16, p=0.03). In patients with congestive heart failure, sleep apnoea severity was an independent predictor of nighttime predominant T-wave alternans (OR 1.08; 95% CI 1.01-1.16; P=0.03).
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