Key result
In rats, low sodium intake increased renal renin and angiotensinogen mRNA levels, which were further modulated by captopril, while atrial ANF mRNA changed slightly.
Authors
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Hypothesis-generating for sodium-RAAS gene regulation in experimental models; leaves open translation to human hypertension management.
Iwao et al. (1988) studied this question. Different sodium intakes and captopril was evaluated on Messenger RNA levels for renin, angiotensinogen and atrial natriuretic factor. In rats, low sodium intake increased renal renin and angiotensinogen mRNA levels, which were further modulated by captopril, while atrial ANF mRNA changed slightly.
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