Key result
Haemodialysis did not consistently raise active or inactive renin, but the proportion of inactive renin was inversely related to active renin in pre-dialysis plasma (p<0.001).
Why the study?
Does haemodialysis alter active and inactive plasma renin concentrations in relation to blood pressure and body weight changes?
Population
70 patients undergoing haemodialysis, including those with one remnant kidney, two remnant kidneys, and…
Design
Cohort
Follow-up
during dialysis
Authors
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Haemodialysis effects on renin forms are inconsistent; leaves open whether inactive-to-active ratio informs pre-dialysis assessment in observational cohorts.
Observational (n=70)
Does haemodialysis alter active and inactive plasma renin concentrations in relation to blood pressure and body weight changes?
p-value: p=<0.001
Haemodialysis does not consistently raise active or inactive plasma renin concentrations, and high active renin is associated with a low inactive-to-active ratio, suggesting preferential secretion or consumption.
Thatcher et al. (2008) conducted an observational in End-stage renal disease requiring haemodialysis (n=70). Haemodialysis was evaluated on Active and inactive plasma renin concentrations (p=<0.001). Haemodialysis did not consistently raise active or inactive renin, but the proportion of inactive renin was inversely related to active renin in pre-dialysis plasma (p<0.001).
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