Population
Critically ill patients (in states of shock and tissue damage) and normal volunteers (blood donors)
Design
Cross-sectional
Authors
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Elevated APRC in critical illness should not yet change practice; leaves open mechanisms and prognostic relevance of altered renin ratios.
Critically ill patients exhibit elevated active plasma renin concentrations and a lowered inactive-to-active ratio, likely reflecting consumption of the zymogen or preferential secretion rather than definitive intravascular activation.
Thatcher et al. (1985) studied this question.
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