What is the clinical evidence from this study?

Study design: Review. Population: Nitroglycerin tolerance. Intervention: Nitroglycerin (NTG).

January 27, 2004The Annual Review of Pharmacology and Toxicology

Biochemical Mechanism of Nitroglycerin Action and Tolerance: Is This Old Mystery Solved?

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Key result

A thionitrate oxidation hypothesis is proposed to link nitrate bioactivation and tolerance development in an overall mechanism.

Design

Review

Authors

HFHo‐Leung FungNorthwestern University

Discussion

Member takes

Implication

Does not alter nitrate prescribing in angina; leaves open experimental validation of the proposed tolerance mechanism.

Structured PICO

Exposure

Nitroglycerin (organic nitrates)

This review proposes a unifying 'thionitrate oxidation hypothesis' to explain the biochemical mechanisms of nitroglycerin bioactivation and tolerance.

Cite This Study

Ho‐Leung Fung (2004) conducted a review in Nitroglycerin tolerance. Nitroglycerin (NTG) was evaluated. A thionitrate oxidation hypothesis is proposed to link nitrate bioactivation and tolerance development in an overall mechanism.

synapsesocial.com/papers/6a930b3a90d586981c41a653 https://doi.org/10.1146/annurev.pharmtox.44.101802.121646

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Biochemical Mechanism of Nitroglycerin Action and Tolerance: Is This Old Mystery Solved?

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Biochemical Mechanism of Nitroglycerin Action and Tolerance: Is This Old Mystery Solved?

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider