Key result
Obese children homozygous for the T585 allele of the Y2R gene had a lower risk of developing hypertension than those carrying the CC and CT genotypes (OR 0.5; 95% CI 0.27-0.88; P=0.03).
Why the study?
Are PYY and Y2R gene variants associated with obesity or hypertension in children and adolescents?
Case-Control (n=479)
Are PYY and Y2R gene variants associated with obesity or hypertension in children and adolescents?
Odds Ratio: 0.5 (95% CI 0.27–0.88)
p-value: p=0.03
Y2R gene variants, specifically the T585 allele, are associated with a reduced risk of hypertension in obese children and adolescents.
Supports Y2R T585 association with lower hypertension risk in obese youth; leaves open clinical utility pending prospective validation.
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Santoro et al. (2008) conducted a case-control in Obesity and hypertension (n=479). Y2R gene variants (T585 allele homozygosity) vs. CC and CT genotypes was evaluated on Risk of developing hypertension (OR 0.5, 95% CI 0.27-0.88, p=0.03). Obese children homozygous for the T585 allele of the Y2R gene had a lower risk of developing hypertension than those carrying the CC and CT genotypes (OR 0.5; 95% CI 0.27-0.88; P=0.03).
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