Key result
Overexpression of Angptl4 promoted colon cancer cell migration and pseudopodia formation, and its expression in human colorectal cancer tissues correlated with larger tumor volume.
Population
41 frozen tumor and matched normal mucosa blocks from patients with colorectal adenocarcinoma, human…
Comparison
Overexpression or knockdown of Angptl4 in colon… vs Empty vector or scrambled shRNA.
Design
Preclinical
Authors
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Angptl4 may promote colorectal cancer metastasis; hypothesis-generating in animal models and should not change practice.
p-value: p=<0.05
Angptl4 overexpression promotes colon cancer cell migration and invasion via cytoskeleton signaling pathways, suggesting a role in colorectal cancer metastasis.
Chao He (2012) studied Colorectal cancer (n=41). Angptl4 overexpression or knockdown vs. Empty vector or scrambled shRNA was evaluated on Cell migration, colony formation, and tumor growth (p=<0.05). Overexpression of Angptl4 promoted colon cancer cell migration and pseudopodia formation, and its expression in human colorectal cancer tissues correlated with larger tumor volume.
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