Key result
Transfection of ANGPTL3 antisense oligodeoxynucleotides into SMMC-7721 cells significantly inhibited ANGPTL3, p38MAPK, and MMP-9 mRNA expression, reducing cell proliferation and invasion.
Why the study?
Does ANGPTL3 antisense oligodeoxynucleotides transfection reduce cell proliferation and invasion in human hepatocellular carcinoma SMMC-7721 cells?
Population
Human hepatocellular carcinoma SMMC-7721 cells in vitro
Design
Preclinical
Authors
Loading...
Supports ANGPTL3 as a potential HCC target in vitro; hypothesis-generating and should not yet change practice.
Does ANGPTL3 antisense oligodeoxynucleotides transfection reduce cell proliferation and invasion in human hepatocellular carcinoma SMMC-7721 cells?
ANGPTL3 antisense oligodeoxynucleotides inhibit proliferation and invasion of hepatocellular carcinoma cells in vitro, suggesting ANGPTL3 as a potential therapeutic target.
Yu et al. (2011) studied Hepatocellular carcinoma (in vitro). ANGPTL3 antisense oligodeoxynucleotides transfection was evaluated on Cell proliferation and invasion capacities, and ANGPTL3, p38MAPK and MMP-9 mRNA expression levels. Transfection of ANGPTL3 antisense oligodeoxynucleotides into SMMC-7721 cells significantly inhibited ANGPTL3, p38MAPK, and MMP-9 mRNA expression, reducing cell proliferation and invasion.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: