Key result
Bursectomized chickens resolved primary infections and prevented replication of challenge virus as effectively as intact chickens, indicating the importance of local cell-mediated immunity.
Local cell-mediated immune mechanisms, rather than humoral immunity, are primarily responsible for the outcome of infection with ILT virus in chickens.
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Local cell-mediated immunity may suffice for ILT control in chickens; leaves open translation to other species or hosts.
Fahey et al. (1990) studied Infectious laryngotracheitis (ILT) herpesvirus infection. Bursectomy (absence of mucosal antibody) vs. Intact chickens was evaluated on Recovery from primary infection and resistance to reinfection. Bursectomized chickens resolved primary infections and prevented replication of challenge virus as effectively as intact chickens, indicating the importance of local cell-mediated immunity.
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