Key result
Infectious laryngotracheitis virus infection in chickens leads to leukopenia, with viral multiplication and cytopathogenic effects observed in leukocytes serving as host cells.
Chicken leukocytes can serve as host cells for ILT virus multiplication, leading to cell destruction and leukopenia.
ILTV leukocyte tropism may underlie leukopenia in infected chickens; in vitro data leave open in vivo pathogenesis and intervention studies.
Infectious laryngotracheitis (ILT) virus, an avian herpesvirus, caused an infection in chickens that was followed by leukopenia due to a decrease in the number of circulating lymphocytes. Viral synthesis in leukocytes in cell cultures was evident by specific and progressive viral antigens in the nuclei of infected leukocytes as shown by fluorescent-antibody technique and by the formation of multinucleated giant cells, typical of the herpesviruses. In addition, viral multiplication was observed in the leukocyte cell cultures as shown by viral assay. It is suggested that the leukocytes in chicken are participating in the production of ILT virus by serving as host cells for viral multiplication. This is followed by a cytopathogenic effect, with the production of multinucleated giant cells. That may result in the destruction of cells, causing a leukopenia.
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Chang et al. (1977) studied Infectious laryngotracheitis (ILT) virus infection. Infectious laryngotracheitis (ILT) virus was evaluated on Viral synthesis and cytopathogenic effect in leukocytes. Infectious laryngotracheitis virus infection in chickens leads to leukopenia, with viral multiplication and cytopathogenic effects observed in leukocytes serving as host cells.
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