Key result
Ultrafine mapping of the Dyscalc1 locus in mice narrowed the region to 80-Kb and identified EMP-3 as a new candidate gene for dystrophic cardiovascular calcification.
Ultrafine mapping identified EMP-3 as a novel candidate gene for dystrophic cardiovascular calcification in mice.
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EMP-3 merits functional validation in mice; leaves open translation to human dystrophic cardiovascular calcification.
Aherrahrou et al. (2006) studied Dystrophic cardiovascular calcification (n=15). Freeze-thaw injury of the heart and genetic mapping vs. DCC-resistant mouse strains was evaluated on Mapping of the Dyscalc1 locus and identification of candidate genes. Ultrafine mapping of the Dyscalc1 locus in mice narrowed the region to 80-Kb and identified EMP-3 as a new candidate gene for dystrophic cardiovascular calcification.
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