Key result
Chemical calcium quantification directly correlates with histological dystrophic cardiac calcification severity in mice.
Why the study?
Dystrophic cardiac calcification severity in mice is commonly assessed histologically, but the potential for chemical calcium analysis as an alternative was unclear.
Chemical analysis of calcium is a viable alternative to histological examination for assessing dystrophic cardiac calcification severity in mice.
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May expedite preclinical DCC assessment in mice; leaves open human validation and translation.
Broek et al. (1997) studied Dystrophic cardiac calcification. Chemical analysis of calcium vs. Histological examination was evaluated on Correlation between DCC scores and calcium contents. Chemical analysis of calcium directly correlated with histological DCC scores within mouse hearts, suggesting it could serve as an alternative assessment method for DCC severity.
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