What question did this study set out to answer?

To characterize the onset, frequency, and progression of heart and aortic calcification lesions in young DBA/2NCrj mice.

Development of heart and aortic lesions in DBA/2NCrj mice

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Provides murine model of age-specific myocardial calcification; leaves open human translational relevance.

To characterize the onset, frequency, and progression of heart and aortic calcification lesions in young DBA/2NCrj mice.
Examined cardiovascular tissues in DBA/2NCrj mice aged 3 to 8 weeks to track lesion emergence and pathology.
Small foci of myocardial calcification appeared from 4 to 8 weeks of age at a stable frequency, whereas severe calcification with inflammation localized below the right ventricular epicardium increased drastically between 6 and 7 weeks.
Aortic lesions featuring calcification of smooth muscle cells and elastic laminae occurred from 3 weeks of age at an age-independent incidence of approximately 50%.

Maeda et al. (1986) studied this question.

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