Key result
Normal male DBA/1 mice showed equivalent cardiac function and structure to C57BL/6J mice over 6 months, indicating their suitability for modeling autoimmune disease-induced heart dysfunction.
Why the study?
Because basic cardiac function differs across mouse strains and C57BL/6J mice have a low incidence of chronic immune diseases to which DBA/1 mice are susceptible, whether normal adult DBA/1 mice have equivalent cardiac function to C57BL/6J mice needed evaluation.
Do normal adult DBA/1 mice have cardiac function and performance equal to those of C57BL/6J mice?
Population
Normal male C57BL/6J and DBA/1 mice up to 8 months old
Comparison
DBA/1 mice vs C57BL/6J mice
Design
Animal comparative study
Follow-up
Six consecutive months
Authors
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Validates DBA/1 mice for autoimmune heart models; leaves open human translation.
Do normal adult DBA/1 mice have cardiac function and performance equal to those of C57BL/6J mice?
DBA/1 mice have equivalent baseline cardiac function to C57BL/6J mice, validating their use as a model for autoimmune-related cardiovascular disease.
Wang et al. (2021) studied Normal cardiac function. DBA/1 mice strain vs. C57BL/6J mice strain was evaluated on Cardiac systolic and diastolic function and structure. Normal male DBA/1 mice showed equivalent cardiac function and structure to C57BL/6J mice over 6 months, indicating their suitability for modeling autoimmune disease-induced heart dysfunction.
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