Key result
A simulated mild mitral valve prolapse condition produced a 40% greater regurgitant volume (p < 0.0001) and 2.6 times more leakage volume compared to the normal condition in an in vitro simulator.
Effect estimate: 40% greater
p-value: p=< 0.0001
An in vitro pulsatile simulator using a porcine mitral valve can successfully model normal hemodynamics and mild mitral valve prolapse, providing a stable platform for quantitative evaluation.
Validates in vitro porcine mitral simulator for regurgitation quantification; leaves open clinical translation pending in vivo studies.
An in vitro pulsatile simulator with a porcine mitral valve was developed in order to simulate physiologic and diseased mitral valve conditions. Evaluation of these conditions was conducted from a hydrodynamic and annulus behavior point of view. We found it possible to simulate mild "mitral valve prolapse" and to obtain quantitative data related to the condition. The diseased condition produced a 40% greater regurgitant volume than that observed under the normal condition (p < 0.0001). Regarding the leakage volume, the diseased condition exhibited about 2.6 times more leakage than the normal condition. The mitral valve simulator proposed in this study is considered fairly stable with respect to both hemodynamics and the behavior of the annulus, and it is an adequate simulator for modeling various types of normal and diseased mitral valve conditions.
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Arita et al. (2004) studied Mitral valve prolapse. Simulated mild mitral valve prolapse vs. Normal condition was evaluated on Regurgitant volume (40% greater, p=< 0.0001). A simulated mild mitral valve prolapse condition produced a 40% greater regurgitant volume (p < 0.0001) and 2.6 times more leakage volume compared to the normal condition in an in vitro simulator.
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