Key result
Orthotopic heart transplant was successfully performed in an 11-year-old girl with mixed connective tissue disease, resulting in no antibody-mediated rejection and improved inflammatory symptoms.
Why the study?
Patients with autoimmune inflammatory syndromes such as mixed connective tissue disease and systemic lupus erythematosus have previously been considered marginal candidates for orthotopic heart transplant.
Does orthotopic heart transplant improve outcomes without antibody-mediated rejection in a pediatric patient with mixed connective tissue disease and refractory heart failure?
Case Report (n=1)
Does orthotopic heart transplant improve outcomes without antibody-mediated rejection in a pediatric patient with mixed connective tissue disease and refractory heart failure?
Orthotopic heart transplant may be a viable and safe option for pediatric patients with mixed connective tissue disease and refractory heart failure, despite their autoimmune status.
May support individualized evaluation in refractory pediatric MCTD-HF; hypothesis-generating and should not yet change practice.
BACKGROUND: Patients with autoimmune inflammatory syndromes such as mixed connective tissue disease (MCTD) and systemic lupus erythematosus have previously been considered marginal candidates for orthotopic heart transplant (OHT). METHODS: A retrospective chart review was completed for this case report. RESULTS: We present the case of an 11-year-old girl with known MCTD who developed congestive heart failure refractory to medical therapy and underwent OHT. CONCLUSIONS: Despite her autoimmune condition, this patient has not experienced antibody-mediated rejection post-transplant and her inflammatory symptoms have greatly improved.
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Miller et al. (2021) conducted a case report in Mixed connective tissue disease and congestive heart failure (n=1). Orthotopic heart transplant was evaluated on Antibody-mediated rejection post-transplant and inflammatory symptoms. Orthotopic heart transplant was successfully performed in an 11-year-old girl with mixed connective tissue disease, resulting in no antibody-mediated rejection and improved inflammatory symptoms.
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