Key result
Elevated BNP in clinically quiescent heart transplant recipients significantly correlated with gene expression profiles indicating structural remodeling, vascular injury, and inflammation (P<0.001).
Cross-Sectional (n=28)
p-value: p=<0.001
In clinically quiescent heart transplant recipients, elevated BNP correlates with gene expression profiles indicative of structural remodeling, vascular injury, and alloimmune processes, suggesting it reflects active allograft injury and repair rather than just hemodynamics.
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May indicate subclinical allograft injury in stable recipients; hypothesis-generating for BNP-guided surveillance.
Mehra et al. (2006) conducted a cross-sectional in Heart transplantation (n=28). Elevated B-type natriuretic peptide (BNP) concentrations was evaluated on Correlation of peripheral gene expression signatures with BNP concentrations (p=<0.001). Elevated BNP in clinically quiescent heart transplant recipients significantly correlated with gene expression profiles indicating structural remodeling, vascular injury, and inflammation (P<0.001).
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