Key result
BNP plasma levels in heart transplant recipients significantly correlated with female gender (P=0.006), time post-transplant (P=0.006), donor age (P=0.007), and transplant vasculopathy (P=0.03).
Why the study?
What are the clinical, demographic, and hemodynamic determinants of BNP plasma levels in stable long-term heart transplant recipients?
Cross-Sectional (n=105)
What are the clinical, demographic, and hemodynamic determinants of BNP plasma levels in stable long-term heart transplant recipients?
BNP levels in stable heart transplant recipients are influenced by female gender, renal function, time post-transplant, donor age, and transplant vasculopathy.
BNP interpretation in stable transplant recipients requires adjustment for non-hemodynamic factors; hypothesis-generating for vasculopathy monitoring.
Determinants of B-type natriuretic peptide (BNP) plasma levels in the chronic phase after heart transplantation remain unclear. BNP was measured in 105 stable long-term heart transplant recipients with normal left ventricular function by echocardiography and correlated with clinical, demographic and hemodynamic parameters. Multivariate analysis revealed a significant correlation of BNP with female recipient gender (P = 0.006), time post-transplant (P =0.006), donor age (P = 0.007), angiographic signs of transplant vasculopathy (TVP) (P = 0.03), serum creatinine level (P = 0.04), and a strong trend for diastolic dysfunction (P = 0.09). Donor gender, recipient age, cyclosporin A blood levels, rejection history, and pulmonary artery pressure had no independent effect on BNP. BNP after heart transplantation appears to be influenced both by established general determinants (female gender, renal function) and transplant-specific determinants such as time post-transplant, donor age and potentially also TVP. In order to determine the value of BNP as a potential surrogate marker of TVP serial intraindividual measurements appear appropriate.
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Klingenberg et al. (2005) conducted a cross-sectional in Heart transplantation (n=105). Clinical, demographic, and hemodynamic parameters was evaluated on B-type natriuretic peptide (BNP) plasma levels. BNP plasma levels in heart transplant recipients significantly correlated with female gender (P=0.006), time post-transplant (P=0.006), donor age (P=0.007), and transplant vasculopathy (P=0.03).
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