Key result
Higher body mass index was independently associated with a reduced risk of all-cause death or unplanned heart failure hospitalization (HR 0.930 per 1-unit increase) in Japanese patients with congestive heart failure.
Why the study?
Does a higher body mass index improve clinical outcomes in Japanese patients hospitalized with congestive heart failure?
Cohort (n=219)
No
Does a higher body mass index improve clinical outcomes in Japanese patients hospitalized with congestive heart failure?
In Japanese patients hospitalized with congestive heart failure, a higher body mass index is independently associated with better clinical outcomes, confirming the existence of an obesity paradox in this population.
Answers are grounded in this paper and cite their sources.
Should not alter BMI management in Japanese HF; extends obesity paradox evidence but remains hypothesis-generating.
BACKGROUND: Obesity has recently been shown to have a favorable effect on the prognosis of patients with congestive heart failure (CHF), but only a few such studies are available in Japan. The purpose of the present study was to investigate whether the obesity paradox is still present after adjusting for CHF characteristics. METHODS AND RESULTS: A total of 219 patients hospitalized with CHF were reviewed, and the impact of body mass index (BMI) on prognosis was examined. Patients were divided into 4 groups according to BMI quartiles. The endpoint was defined as all-cause death or unplanned CHF hospitalization. According to univariate analysis, a higher BMI was associated with better outcomes. High-BMI patients were younger, likely to be male, and had a higher prevalence of hypertension and diabetes. The plasma B-type natriuretic peptide (BNP) levels and blood urea nitrogen (BUN) levels were lower, while the serum hemoglobin and sodium levels were higher in high-BMI patients. The prevalence of atrial fibrillation was lower in high-BMI patients. Predictors for all-cause death or CHF hospitalization based on univariate analysis were age, prior CHF hospitalization, estimated glomerular filtration rate, plasma BNP levels, BUN levels, and serum hemoglobin and sodium levels. According to multivariate analysis, a high BMI was still associated with better outcomes. CONCLUSIONS: High BMI was associated with better clinical outcomes in Japanese CHF patients.
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Komukai et al. (2011) conducted a cohort in Congestive heart failure (n=219). Body mass index vs. Lower body mass index was evaluated on All-cause death or unplanned CHF hospitalization (HR 0.930, 95% CI 0.870-0.994, p=0.033). Higher body mass index was independently associated with a reduced risk of all-cause death or unplanned heart failure hospitalization (HR 0.930 per 1-unit increase) in Japanese patients with congestive heart failure.
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