Key result
Early passage strains of the poliomyelitis virus exhibit qualitative immunological differences that correlate with their epidemic source.
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Highlights potential source-dependent viral variation for outbreak monitoring; leaves open clinical translation to strain-targeted interventions.
Qualitative immunological differences exist between early passage strains or so called human strains of the virus of poliomyelitis. These differences show a relationship to the epidemic source of the virus and are exemplified in this study by 4 strains isolated in different years during an eastern and western epidemic of poliomyelitis.
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Trask et al. (1937) studied this question. Early passage strains of the poliomyelitis virus exhibit qualitative immunological differences that correlate with their epidemic source.
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