Key result
Treatment with cardioselective beta-blockers at the time of first MI was associated with an increased risk of VT/VF (RR 1.51; 95% CI 1.12-2.03) compared to nonselective beta-blockers.
Why the study?
Does chronic treatment with beta-blockers or calcium antagonists affect infarct size, VT/VF, and in-hospital mortality in patients suffering their first acute myocardial infarction?
Population
7,922 citizens of Malmö, Sweden, hospitalized due to a first acute myocardial infarction between 1973 and 1987
Comparison
Chronic treatment with beta-blockers or calcium… vs Patients not on the specific evaluated treatments
Design
Cohort
Follow-up
In-hospital
Authors
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May indicate higher VT/VF risk with cardioselective beta-blockers at first MI; hypothesis-generating and requires randomized confirmation before practice change.
Cohort (n=7,922)
No
Does chronic treatment with beta-blockers or calcium antagonists affect infarct size, VT/VF, and in-hospital mortality in patients suffering their first acute myocardial infarction?
Relative Risk: 1.51 (95% CI 1.12–2.03)
Chronic treatment with nonselective beta-blockers may reduce infarct size, while cardioselective beta-blockers and calcium antagonists are associated with an increased risk of VT/VF during a first acute MI, though none affect in-hospital mortality.
Hansen et al. (2008) conducted a cohort in Acute myocardial infarction (n=7,922). Cardioselective beta-blockers vs. Nonselective beta-blockers was evaluated on Circulatory arrests from ventricular tachycardia/ventricular fibrillation (VT/VF) (RR 1.51, 95% CI 1.12-2.03). Treatment with cardioselective beta-blockers at the time of first MI was associated with an increased risk of VT/VF (RR 1.51; 95% CI 1.12-2.03) compared to nonselective beta-blockers.
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