Key result
Exercise-induced albuminuria following a standardized treadmill test may be useful for the early diagnosis of kidney damage in adolescents with type 1 diabetes (p=0.09).
Why the study?
Does standardized treadmill exercise reveal abnormal albuminuria or blood pressure variations in adolescents with type 1 diabetes compared to healthy controls?
Case-Control (n=40)
No
Does standardized treadmill exercise reveal abnormal albuminuria or blood pressure variations in adolescents with type 1 diabetes compared to healthy controls?
p-value: p=0.09
Exercise-induced albuminuria may serve as a useful early marker for kidney damage in adolescents with type 1 diabetes.
Exercise-induced albuminuria may aid early nephropathy detection in type 1 diabetes adolescents; hypothesis-generating and requires prospective validation before clinical use.
AIM: To investigated the relationship between exercise-induced ambulatory blood pressure measurement (ABPM) abnormalities in type 1 diabetes mellitus (T1DM) adolescents. METHODS: We conducted a case-control at the National Obesity Center of the Yaoundé Central Hospital, Cameroon. We compared 24 h ABPM and urinary albumin-to-creatinine ratio (ACR) at rest and after a standardized treadmill exercise between 20 Cameroonian T1DM patients and 20 matched controls. T1DM adolescents were aged 12-18 years, with diabetes for at least one year, without proteinuria, with normal office blood pressure (BP) and renal function according to the general reference population. Non-diabetic controls were adolescents of general population matched for sex, age and BMI. CONCLUSION: Exercise-induced albuminuria could be useful for early diagnosis of kidney damage in adolescents with T1DM.
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Meli et al. (2017) conducted a case-control in Type 1 diabetes mellitus (n=40). Type 1 diabetes mellitus (with standardized treadmill exercise) vs. Non-diabetic matched controls was evaluated on 24 h ambulatory blood pressure measurement (ABPM) and urinary albumin-to-creatinine ratio (ACR) at rest and after a standardized treadmill exercise (p=0.09). Exercise-induced albuminuria following a standardized treadmill test may be useful for the early diagnosis of kidney damage in adolescents with type 1 diabetes (p=0.09).
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