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August 30, 2023Open Access

Blood pressure parameters and its association with albuminuria in adolescents with type 1 diabetes mellitus and ABPM using Mobil-O-Graph.

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Why the study?

The study aimed to evaluate blood pressure status—including circadian profile, arterial stiffness parameters, and hemodynamic indicators—and its association with albuminuria in adolescents with type 1 diabetes mellitus.

Does ambulatory blood pressure monitoring identify associations between blood pressure parameters, arterial stiffness, and albuminuria in adolescents with type 1 diabetes mellitus?

Population

46 adolescents with type 1 diabetes mellitus

Comparison

BP parameters and hemodynamic indicators compared across albuminuria and BP status

Design

Cross-sectional study

Authors

JSJolanta SołtysiakPoznan University of Medical SciencesBSBogda SkowrońskaPoznan University of Medical SciencesKMKatarzyna Maćkowiak-LewandowiczPoznan University of Medical Sciences

Discussion

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Implication

ABPM parameters may link to albuminuria in T1DM adolescents; leaves open whether they improve early risk stratification.

Structured PICO

Does ambulatory blood pressure monitoring identify associations between blood pressure parameters, arterial stiffness, and albuminuria in adolescents with type 1 diabetes mellitus?

P
Population
46 adolescents with type 1 diabetes mellitus (average diabetes duration 7.38 ± 3.48 years) and 15 healthy control children.
I
Intervention
Ambulatory blood pressure monitoring (ABPM) using the Mobil-O-Graph device (Pulse Wave Analysis Monitor).
C
Comparator
Healthy control children (n=15) and internal comparisons between normotensive, prehypertensive, and hypertensive diabetic patients.
O
Outcome
Blood pressure status (hypertension, prehypertension, normotension), circadian profile, arterial stiffness parameters (PWV, AIx@75), hemodynamic indicators, and their association with urinary albumin excretion (UAE).surrogate

Hypertension is common in adolescents with type 1 diabetes and is primarily driven by nocturnal diastolic BP elevations and arterial stiffness, which correlate with early signs of vascular disease such as albuminuria.

Limitations

  • Retrospective analysis
  • Small number of patients with confirmed diabetic kidney disease

Cite This Study

Sołtysiak et al. (2023) studied this question.

synapsesocial.com/papers/6a75f99bd01cd5d9a170726ehttps://doi.org/10.21203/rs.3.rs-3245475/v1
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