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October 1, 2015Therapeutics and Clinical Risk ManagementOpen Access

Study of ambulatory blood pressure in diabetic children: prediction of early renal insult

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Why the study?

Does ambulatory blood pressure monitoring detect early blood pressure changes in normotensive type 1 diabetic children compared to healthy controls?

Population

40 normotensive type 1 diabetic children and 24 healthy age- and sex-matched children as a control group.

Comparison

Ambulatory blood pressure monitoring vs Healthy age- and sex-matched children

Design

Case-control

Authors

NSNehad ShalabyNSNaglaa M. ShalabyNorthern Border University

Discussion

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Implication

Supports ABPM for early BP detection in normotensive T1DM children; leaves open links to outcomes and need for prospective validation.

Structured PICO

Does ambulatory blood pressure monitoring detect early blood pressure changes in normotensive type 1 diabetic children compared to healthy controls?

P
Population
40 normotensive type 1 diabetic children (mean age 11.56±2.82 years) and 24 healthy age- and sex-matched children as a control group (total n=64).
I
Intervention
Ambulatory blood pressure monitoring (observational exposure to Type 1 diabetes mellitus)
C
Comparator
Healthy age- and sex-matched children
O
Outcome
Blood pressure indices and standard deviation scores (z-scores)surrogate

Ambulatory blood pressure monitoring reveals significant early BP changes and nocturnal non-dipping in normotensive type 1 diabetic children, which correlate with microalbuminuria and may predict future renal and cardiovascular risk.

Cite This Study

Shalaby et al. (2015) studied this question.

synapsesocial.com/papers/6a7e610555c19762e2b29fcehttps://doi.org/10.2147/tcrm.s87751
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ambulatory blood pressure monitoring in children and adolescents with type-1 diabetes mellitus and its relation to diabetic control and microalbuminuria.2012 · 24 citations
  2. 2Ambulatory blood pressure monitoring: fancy gadgetry or clinically useful exercise?2001 · 19 citations
  3. 3Impaired vascular function during short‐term poor glycaemic control in Type 1 diabetic patients2005 · 41 citations
  4. 4Ambulatory blood pressure monitoring in children and adolescents2000 · 31 citations
  5. 5Validation of the custo screen 400 ambulatory blood pressure-monitoring device according to the European Society of Hypertension International Protocol revision 20102014 · 15 citations