Key result
Altered 24-hour blood pressure parameters in children with type 1 diabetes were associated with microvascular complications, with affected children having +0.1 to +0.75 SDS higher BP parameters.
Why the study?
Are altered 24-hour ambulatory blood pressure profiles associated with microvascular complications in children and adolescents with type 1 diabetes?
Population
3,529 children and adolescents (<20 years of age) with type 1 diabetes mellitus documented in the DPV registry
Comparison
Ambulatory blood pressure monitoring parameters… vs Healthy German controls and children with type 1…
Design
Cohort
Authors
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ABPM abnormalities including pulse pressure and variability associate with microvascular complications in pediatric T1D; leaves open whether targeting them alters risk.
Observational (n=3,529)
Yes
Are altered 24-hour ambulatory blood pressure profiles associated with microvascular complications in children and adolescents with type 1 diabetes?
In children and adolescents with type 1 diabetes, altered 24-hour blood pressure regulation, including reverse dipping of pulse pressure, is closely linked to the development of microvascular complications.
Dost et al. (2017) conducted an observational in Type 1 diabetes mellitus (n=3,529). Ambulatory blood pressure parameters vs. Healthy controls / Patients without complications was evaluated on Microalbuminuria and diabetic retinopathy. Altered 24-hour blood pressure parameters in children with type 1 diabetes were associated with microvascular complications, with affected children having +0.1 to +0.75 SDS higher BP parameters.
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