Key result
Duchenne muscular dystrophy patients had significantly prolonged global native T1 relaxation times compared to controls (1041 and 1043 ms vs. 983 ms, p < 0.05) independent of the presence of myocardial fibrosis.
Why the study?
Data on using parametric imaging in patients with DMD are limited, prompting an assessment of native T1 and ECV values.
Does cardiac magnetic resonance with T1 mapping detect early myocardial involvement in males with Duchenne muscular dystrophy compared to controls?
Observational (n=56)
Yes
Does cardiac magnetic resonance with T1 mapping detect early myocardial involvement in males with Duchenne muscular dystrophy compared to controls?
Absolute Event Rate: 1041% vs 983%
p-value: p=<0.05
Native T1 mapping by cardiac magnetic resonance can detect early myocardial involvement in Duchenne muscular dystrophy patients prior to the development of late gadolinium enhancement or left ventricular dysfunction.
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Supports native T1 for detecting preclinical DMD cardiac involvement; leaves open its prognostic value and therapeutic implications.
Panovský et al. (2019) conducted an observational in Duchenne muscular dystrophy (n=56). Duchenne muscular dystrophy vs. Healthy controls was evaluated on Global native T1 relaxation time (p=<0.05). Duchenne muscular dystrophy patients had significantly prolonged global native T1 relaxation times compared to controls (1041 and 1043 ms vs. 983 ms, p < 0.05) independent of the presence of myocardial fibrosis.
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