Key result
Native T1 values were significantly higher in the LGE-spared septal myocardium of boys with Duchenne muscular dystrophy compared to controls (1046.1 vs 989.9 ms using MOLLI, p<0.001), identifying early subclinical disease.
Why the study?
Do native T1 and ECV measurements identify myocardial changes and stratify disease severity in boys with Duchenne muscular dystrophy compared to controls?
Population
20 boys with Duchenne muscular dystrophy and 16 age/gender-matched controls without history predisposing to…
Comparison
Native T1 and extracellular volume regional… vs Age/gender-matched controls without history…
Design
Case-control
Authors
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May detect early subclinical myocardial changes in Duchenne muscular dystrophy; leaves open validation for severity stratification or clinical use.
Cross-Sectional (n=36)
No
Do native T1 and ECV measurements identify myocardial changes and stratify disease severity in boys with Duchenne muscular dystrophy compared to controls?
Absolute Event Rate: 1046.1% vs 989.9%
p-value: p=<0.001
Native T1 mapping can identify early myocardial changes in Duchenne muscular dystrophy patients prior to the appearance of late gadolinium enhancement, serving as a potential marker for disease severity.
Olivieri et al. (2016) conducted a cross-sectional in Duchenne muscular dystrophy (n=36). Duchenne muscular dystrophy vs. Age-matched controls was evaluated on Septal native T1 value (MOLLI) (p=<0.001). Native T1 values were significantly higher in the LGE-spared septal myocardium of boys with Duchenne muscular dystrophy compared to controls (1046.1 vs 989.9 ms using MOLLI, p<0.001), identifying early subclinical disease.
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