Key result
Rats with cardiac failure exhibited significantly smaller increases in renal sympathetic nerve activity after sinoaortic denervation and vagotomy compared to normal controls (42% vs 87%, P<0.05).
Population
Anesthetized normal control rats and rats with cardiac failure induced by left coronary ligation
Comparison
Sequential random order sinoaortic denervation… vs Normal control rats
Design
Preclinical, Sequential random order
Authors
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Supports predominant cardiac baroreflex impairment in experimental heart failure; hypothesis-generating and requires human validation before any clinical consideration.
Absolute Event Rate: 42% vs 87%
p-value: p=< 0.05
In a rat model of cardiac failure, the impairment of cardiac baroreceptor reflex function is greater than that of arterial baroreceptor reflex function in contributing to increased renal sympathetic nerve activity.
DiBona et al. (1995) studied Cardiac failure. Cardiac failure vs. Normal control rats was evaluated on Increases in renal sympathetic nerve activity after combined sinoaortic denervation and vagotomy (p=< 0.05). Rats with cardiac failure exhibited significantly smaller increases in renal sympathetic nerve activity after sinoaortic denervation and vagotomy compared to normal controls (42% vs 87%, P<0.05).
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