Key result
High-dose ziprasidone (240-320 mg/day) yielded an average QTc interval increase of 3.4 msec, with no cases having an increase >20 msec or reaching the 500 msec threshold of concern.
Why the study?
Does high-dose ziprasidone cause significant QTc interval prolongation in adult inpatients with intractable psychotic symptoms?
Population
15 adult inpatients with intractable psychotic symptoms at the James A. Haley Veterans Affairs Medical Center
Comparison
High-dose ziprasidone (240 to 320 mg/day) vs Pre-treatment baseline QTc intervals
Design
Case_series
Authors
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May support high-dose ziprasidone without added QTc concern in select inpatients; leaves open confirmation in randomized studies.
Observational (n=15)
No
Does high-dose ziprasidone cause significant QTc interval prolongation in adult inpatients with intractable psychotic symptoms?
Mean Difference: 3.4
High-dose ziprasidone (240-320 mg/day) did not cause clinically significant QTc prolongation in a small cohort of adult inpatients.
Levy et al. (2004) conducted an observational in Intractable psychotic symptoms (n=15). High-dose ziprasidone vs. Pre-treatment baseline was evaluated on QTc interval changes from pre- to post-treatment (average increase of 3.4 msec). High-dose ziprasidone (240-320 mg/day) yielded an average QTc interval increase of 3.4 msec, with no cases having an increase >20 msec or reaching the 500 msec threshold of concern.
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