Key result
Ziprasidone and bupropion overdose was associated with a widened QRS and prolonged QTc interval requiring aggressive cardiac monitoring and antidysrhythmic therapy.
Case Report (n=1)
Intentional overdose of ziprasidone and bupropion can lead to severe cardiotoxicity, including widened QRS and prolonged QTc interval, requiring aggressive monitoring.
Case-level data support monitoring for cardiotoxicity in ziprasidone-bupropion overdose; leaves open generalizability and optimal therapies.
BACKGROUND: Ziprasidone and bupropion are medications prescribed for mood and behavior disorders. They have apparently safe cardiac safety profiles in both therapeutic and supratherapeutic doses, but recently the Federal Drug Administration has issued a caution regarding ziprasidone use in combination with other drugs that are known to prolong the QTc interval. CASE REPORT: A 17-year-old male developed a widened QRS and a prolonged QTc interval following an overdose of ziprasidone and bupropion. He required hospital admission for aggressive cardiac monitoring and antidysrhythmic therapy, stabilizing to baseline by 80 hours postingestion. CONCLUSIONS: We present a case that underscores the potential cardiotoxicities of these medications. Ziprasidone and bupropion ingestion can be associated with cardiotoxicities that may require several days of aggressive cardiac monitoring and treatment.
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Biswas et al. (2003) conducted a case report in Ziprasidone and bupropion overdose (n=1). Ziprasidone and bupropion overdose was evaluated on Cardiotoxicity (widened QRS and prolonged QTc interval). Ziprasidone and bupropion overdose was associated with a widened QRS and prolonged QTc interval requiring aggressive cardiac monitoring and antidysrhythmic therapy.
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