Key result
Bupropion-associated QRS prolongation was unresponsive to intravenous bolus therapy of sodium bicarbonate.
Why the study?
Does intravenous sodium bicarbonate improve bupropion-associated QRS prolongation?
Does intravenous sodium bicarbonate improve bupropion-associated QRS prolongation?
Bupropion-associated QRS prolongation may not respond to standard sodium bicarbonate therapy typically used for similar conduction delays in tricyclic antidepressant overdoses.
Bupropion QRS prolongation may not respond to sodium bicarbonate; leaves open optimal management strategies in overdose.
We describe a case of bupropion-associated QRS prolongation that was unresponsive to intravenous bolus therapy of sodium bicarbonate. Bupropion may cause seizures and conduction delays similar to tricyclic antidepressants in the overdose setting by an unknown mechanism.
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Wills et al. (2009) studied this question. Bupropion-associated QRS prolongation was unresponsive to intravenous bolus therapy of sodium bicarbonate.
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