Key result
An intentional overdose of ziprasidone and bupropion in a 17-year-old male resulted in a widened QRS and prolonged QTc interval requiring aggressive cardiac monitoring and antidysrhythmic therapy.
Why the study?
Does ziprasidone and bupropion overdose cause cardiotoxicity?
Case Report (n=1)
Does ziprasidone and bupropion overdose cause cardiotoxicity?
Ziprasidone and bupropion overdose can cause significant cardiotoxicity requiring aggressive monitoring and treatment.
Overdose of ziprasidone plus bupropion may cause QRS widening and QTc prolongation needing monitoring; this case leaves open true incidence and optimal management.
BACKGROUND: Ziprasidone (Geodon) and bupropion (Wellbutrin) are medications prescribed for mood and behavior disorders. They have apparently safe cardiac safety profiles in both therapeutic and supra-therapeutic doses. CASE REPORT: A 17-year-old male developed a widened QRS and a prolonged QTc interval following an overdose of ziprasidone and bupropion. He required hospital admission for aggressive cardiac monitoring and antidysrhythmic therapy, stabilizing to baseline by 80 hours post-ingestion. CONCLUSIONS: We present a case that underscores the potential cardiotoxicities of these medications. Ziprasidone and bupropion ingestion can be associated with cardiotoxicities that may require several days of aggressive cardiac monitoring and treatment.
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Biswas et al. (2003) conducted a case report in Intentional ziprasidone and bupropion overdose (n=1). Ziprasidone and bupropion overdose was evaluated on Cardiotoxicity (widened QRS and prolonged QTc interval). An intentional overdose of ziprasidone and bupropion in a 17-year-old male resulted in a widened QRS and prolonged QTc interval requiring aggressive cardiac monitoring and antidysrhythmic therapy.
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