Key result
Monoclonal antibodies reactive with epitopes on the hemagglutinin-neuraminidase glycoprotein of mumps virus protected infected newborn hamsters from lethal central nervous system infection.
Why the study?
Does monoclonal antibody therapy protect against lethal mumps virus meningoencephalitis in newborn Syrian hamsters?
Population
Newborn Syrian hamsters challenged with an intracerebral inoculum containing 128 50% lethal doses of the…
Design
Preclinical
Authors
Loading...
Anti-HN mAb protection in hamster CNS infection is hypothesis-generating; leaves open translation to human neonatal meningoencephalitis.
Does monoclonal antibody therapy protect against lethal mumps virus meningoencephalitis in newborn Syrian hamsters?
Monoclonal antibodies targeting the hemagglutinin-neuraminidase glycoprotein of mumps virus provide protection against lethal meningoencephalitis in a hamster model.
Wolinsky et al. (1985) studied Experimental mumps virus meningoencephalitis. Monoclonal antibodies reactive with epitopes on the hemagglutinin-neuraminidase glycoprotein of mumps virus vs. Monoclonal antibodies reactive with epitopes on the fusion glycoprotein was evaluated on Protection against lethal central nervous system virus infection. Monoclonal antibodies reactive with epitopes on the hemagglutinin-neuraminidase glycoprotein of mumps virus protected infected newborn hamsters from lethal central nervous system infection.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: