Key result
Familial acute aortic dissection without Marfan syndrome affected a mother and three of four siblings, with all siblings successfully treated by surgery and well 6-42 months later.
Highlights a rare familial clustering of acute aortic dissection in the absence of Marfan syndrome, with successful surgical outcomes.
May prompt family screening in aortic dissection; leaves open unidentified genetic factors beyond Marfan.
Acute aortic dissection occurred in three of four siblings without Marfan syndrome. All of them were successfully treated by operation and remain well 6-42 months after operation. Their mother died suddenly in another hospital of acute aortic dissection. All her siblings were dead and cardiovascular disease was suspected in all of them.
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Toyama et al. (1989) studied this question. Familial acute aortic dissection without Marfan syndrome affected a mother and three of four siblings, with all siblings successfully treated by surgery and well 6-42 months later.
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