Key result
Patients whose flow improved from TIMI grade 2 at 90 minutes to TIMI grade 3 by 5-7 days had a higher mean ejection fraction (57.5% vs 52.8%, P=0.02) than those with persistent TIMI grade 2 flow.
Why the study?
Does improvement from early TIMI grade 2 to TIMI grade 3 flow improve left ventricular function in patients with acute myocardial infarction treated with thrombolysis?
Observational (n=914)
Yes
Does improvement from early TIMI grade 2 to TIMI grade 3 flow improve left ventricular function in patients with acute myocardial infarction treated with thrombolysis?
Absolute Event Rate: 57.5% vs 52.8%
p-value: p=0.02
Incomplete clot lysis contributes to early TIMI 2 flow after thrombolysis, but flow often improves to TIMI 3 by 5-7 days, which is associated with better recovery of left ventricular function.
No takes yet. Share an insight, caveat, or question.
Late TIMI 2-to-3 improvement was associated with higher ejection fraction; hypothesis-generating for whether late intervention benefits persistent TIMI 2 flow after thrombolysis.
Reiner et al. (1996) conducted an observational in Acute Myocardial Infarction (n=914). Improvement to TIMI grade 3 flow at 5-7 days vs. Persistent TIMI grade 2 flow was evaluated on Mean ejection fraction at 5- to 7-day follow-up (p=0.02). Patients whose flow improved from TIMI grade 2 at 90 minutes to TIMI grade 3 by 5-7 days had a higher mean ejection fraction (57.5% vs 52.8%, P=0.02) than those with persistent TIMI grade 2 flow.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: