Key result
Brown fat cells contain sympathetic nerve fibers with synaptic varicosities running between all cells, whereas white fat lacks sympathetic innervation of parenchymal cells.
Demonstrates that brown fat, unlike white fat, has direct sympathetic innervation of parenchymal cells.
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May guide brown fat-targeted metabolic therapies; leaves open human translation from animal innervation data.
By using a modified method of Falck, the distribution of nerves containing catecholamines in brown and white fat was studied. The brown fat cells had sympathetic nerve fibers with synaptic varicosities running between all cells. White fat had no sympathetic innervation of the parenchymal cells. Both tissues contained a dense network of fibers around the arterial blood vessels.
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Daniel et al. (1969) studied this question. Brown fat cells contain sympathetic nerve fibers with synaptic varicosities running between all cells, whereas white fat lacks sympathetic innervation of parenchymal cells.
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