Key result
Offspring of two hypertensive parents had higher mean 24-hour systolic blood pressure (difference 4.7 mm Hg; 95% CI 1.8-7.6) compared with offspring of two normotensive parents.
Observational
Mean Difference: 4.7 (95% CI 1.8–7.6)
Early primary hypertension in children with a strong family history is characterized by increased left ventricular mass rather than a hyperkinetic circulatory state.
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May support earlier ambulatory BP assessment in children with dual parental hypertension; leaves open causal links and screening thresholds.
Hooft et al. (1993) conducted an observational in Early phase of primary hypertension. Familial predisposition for hypertension (offspring of two hypertensive parents) vs. Offspring of two normotensive parents was evaluated on Mean 24-hour systolic blood pressure (MD 4.7 mm Hg, 95% CI 1.8-7.6). Offspring of two hypertensive parents had higher mean 24-hour systolic blood pressure (difference 4.7 mm Hg; 95% CI 1.8-7.6) compared with offspring of two normotensive parents.
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