Key result
Aprosulate sodium inhibited thrombin-induced platelet aggregation in a concentration-dependent manner with an IC50 of 0.38 microgram/ml, independent of its anticoagulant activity.
Why the study?
Does aprosulate sodium inhibit platelet activation in vitro?
Population
Rat washed platelets and human platelets in a plasma-free system
Comparison
Aprosulate sodium (up to 10 micrograms/ml) vs Heparin
Design
Preclinical
Authors
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In vitro platelet inhibition by aprosulate sodium may support dual-action investigation; hypothesis-generating and requires in vivo validation before clinical consideration.
Does aprosulate sodium inhibit platelet activation in vitro?
Aprosulate sodium is a novel anticoagulant that inhibits thrombin-induced platelet activation in vitro, likely by blocking the platelet-thrombin interaction.
Sugidachi et al. (1996) studied Platelet aggregation. Aprosulate sodium vs. Heparin was evaluated on Thrombin-induced platelet aggregation. Aprosulate sodium inhibited thrombin-induced platelet aggregation in a concentration-dependent manner with an IC50 of 0.38 microgram/ml, independent of its anticoagulant activity.
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