Key result
Bis-aldonic acid amides, particularly LW 10121, exhibited antithrombotic and anticoagulant activities in rats, with LW 10121 showing a longer duration of action than aprosulate and heparin.
Population
Rat jugular vein hemostasis model and in vitro assays
Comparison
Bis-aldonic acid amides vs Aprosulate and heparin
Design
Preclinical
Authors
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No immediate clinical implications from rat data; leaves open whether bis-aldonic acid amides advance to human trials.
Bis-aldonic acid amides, particularly LW 10121, demonstrate promising antithrombotic and anticoagulant activities in preclinical models.
Raake et al. (1994) studied Thrombosis. Bis-aldonic acid amides (e.g., LW 10121) vs. Aprosulate and heparin was evaluated on Anticoagulant activity (APTT prolongation) and antithrombotic activity (jugular vein hemostasis model). Bis-aldonic acid amides, particularly LW 10121, exhibited antithrombotic and anticoagulant activities in rats, with LW 10121 showing a longer duration of action than aprosulate and heparin.
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