Key result
In patients with cryptogenic stroke, the estimated atrial fibrillation detection rate using an implantable loop recorder was 28.6% at 36 months follow-up.
Why the study?
Real-world data regarding the long-term rate of AF detection using ILR and subsequent management consequences in patients with cryptogenic stroke are limited.
What is the real-world rate of atrial fibrillation detection using an implantable loop recorder in patients with cryptogenic stroke?
Cohort (n=225)
No
What is the real-world rate of atrial fibrillation detection using an implantable loop recorder in patients with cryptogenic stroke?
Real-world use of implantable loop recorders in cryptogenic stroke patients yields a 36-month AF detection rate of 28.6%, consistent with clinical trials, though false-positive detections are common.
May support prolonged ILR use in cryptogenic stroke; leaves open optimal duration and outcomes in prospective trials.
Purpose Implantable loop recorders (ILR) are used to screen for atrial fibrillation (AF) in patients with cryptogenic stroke (CS). However, there is limited real-world data regarding the long-term rate of AF detection using ILR and management consequences in patients with CS. The objective is to assess the rate of AF detection in patients with CS in a real-world study over 36 months of follow-up and its consequences on stroke prevention. Methods This retrospective study included patients with an ILR placed for CS at Baylor College of Medicine and Baylor St. Luke’s Medical Center between January 2014 and July 2021. The primary outcome was AF detection in patients with ILR. The secondary outcome was the rate of subsequent strokes after ILR placement in patients with or without diagnosed AF. The AF detection rate in our cohort was compared to the rate in CRYSTAL-AF Trial at 36-month follow-up. The impact of AF detection on clinical management was examined. Results We identified 225 patients. 51.1% were women and 38.2% African American. Among 85 patients with ILR labeled AF, 43 patients had true AF, and 42 had incorrectly labeled AF (48.3% false positive). The estimated AF detection rate at 36 months follow-up was 28.6% (95% CI, 26.6%-30.6%). 58.1% of patients with AF were initiated on oral anticoagulation, 80.0% of whom were started on a direct oral anticoagulant. 13.8% of patients had recurrent strokes after ILR implantation; 4 of whom were diagnosed with AF. Conclusion Compared to CRYSTAL-AF, the AF detection rate in our cohort is similar, but this cohort includes a higher proportion of female and African American patients. Most patients with recurrent strokes after ILR implant did not have AF during 36 months of monitoring.
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Kim et al. (2022) conducted a cohort in Cryptogenic stroke (n=225). Implantable loop recorder was evaluated on Atrial fibrillation detection (95% CI 26.6%-30.6%). In patients with cryptogenic stroke, the estimated atrial fibrillation detection rate using an implantable loop recorder was 28.6% at 36 months follow-up.
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